Following drugs undergo high first pass metabolism in liver:
V. Verapamil
P. Propanolol
Singh Salbutamol
Not Nitroglycerine
A Amitriptyline
Popular Propoxyphene
P. Pethidine
M. Methyltestosterone
Plasma protein binding:
Acidic drugs are bound with Albumin (while basic drugs are bound with glycoproteins)
Following drugs are Hepatic Enzyme Inducers:
H Habits like Chr. Alcoholism, Cigarette smoking, Charcoal broiled meat, Chloral hydrate (sleep inducing drug)
E Epilepsy drugs e.g. Phenobarbitone, Phenytoin, Primidone, Carbamazepine
I INH and Rifampicin (Anti-tubercular drugs)
Zero order kinetics is seen with:
(Zero WATT bulb to be remembered)
W Warfarin
A Alcohol & Antiepileptic phenytoin
T Tolbutamide
T Theophylline
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