FIRST line drugs:[HRZSE]
F Field defects causing drug i.e. Ethambutol [E]
I Isoniazid (INH) [H]
R Rifampicin [R]
S Streptomycin [S]
T Twice a day given drug i.e. Pyrazinamide [Z]
(All other first line antituberculars are given once a day)
SECOND line drugs:
S Salicylates like Para-amino salicylate
E Ethionamide
C Cycloserine
O Old drug: Thiacetazone
N Newer Drugs:
Quinolones e.g. Ciprofloxacin, Ofloxacin
Macrolides e.g. Clarithromycin, Azithromycin
D Drugs rarely used:
Aminoglycosides e.g. Capreomycin, Kanamycin, Amikacin
Adverse effects of first line anti-tubercular drugs:
1. INH: Insanity (i.e. psychosis), optic [for eye(I)]Neuritis, Hepatitis
2. Rifampicin: Red discoloration of urine, induction of liver enzymes and its toxicity, flu like symptoms
3. Pyrazinamide: Pain in the joints which may also be gout due to hyperuricemia (Plus hepatotoxicity)
4. Ethambutol: Eye toxicity – field defects, loss of visual acquity & colour vision
Streptomycin: Similar to all aminoglycosides i.e. nephro-neuro-oto-toxicity
Thanks.Really Helpful
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