Thursday, October 6, 2011

ANTIBIOTICS INTERFERING BACTERIAL PROTEIN SYNTHESIS


AMINOGLYCOSIDES:
A             Active against all aerobic gram –ve bacilli
M            Mechanism: Misreading of mRNA codon, interfering the bacterial protein synthesis
I               Ionize completely in solution (hydrophilic). So do not cross biological membranes,
                therefore  not absorbed orally, remain in ECF & excreted unchanged in urine
N             Nephro-Neuro-toxic; so have a Narrow margin of safety
O             Oto-toxic i.e. vestibular damage causing vertigo & cochlear damage causing
                deafness and tinnitus
G             Gentamicin is the prototype. Other aminoglycosides are:
                Streptomycin, Amikacin, Netilmicin, Neomycin,etc.


MACROLIDES:
M            Main agent i.e. prototype drug used since 1950 is Erythromycin
                Newer analogues are:
A             Azithromycin
C             Clarithromycin
R             Roxithromycin


Clinical uses of macrolides:
(Remember vaccines of national immunization programme
e.g. DPT, Measles, Polio & BCG)
D             Diphtheria
P             Pertusis (=whooping cough)
T              Tetanus
M            Mycoplasma and legionaire’s pneumonia
P             Penicillin alternative in penicillin allergic patients
B             Bacterial diarrhoeas as caused by Campylobacter jejuni
C             Chancroid caused by H. ducreyi
G             Genital infections caused by Chlamydia

3 comments:

  1. Irrespective of receiving daily oral or future injectable depot therapies, these require health care visits for medication and monitoring of safety and response. If patients are treated early enough, before a lot of immune system damage has occurred, life expectancy is close to normal, as long as they remain on successful treatment. However, when patients stop therapy, virus rebounds to high levels in most patients, sometimes associated with severe illness because i have gone through this and even an increased risk of death. The aim of “cure”is ongoing but i still do believe my government made millions of ARV drugs instead of finding a cure. for ongoing therapy and monitoring. ARV alone cannot cure HIV as among the cells that are infected are very long-living CD4 memory cells and possibly other cells that act as long-term reservoirs. HIV can hide in these cells without being detected by the body’s immune system. Therefore even when ART completely blocks subsequent rounds of infection of cells, reservoirs that have been infected before therapy initiation persist and from these reservoirs HIV rebounds if therapy is stopped. “Cure” could either mean an eradication cure, which means to completely rid the body of reservoir virus or a functional HIV cure, where HIV may remain in reservoir cells but rebound to high levels is prevented after therapy interruption.Dr Itua Herbal Medicine makes me believes there is a hope for people suffering from,Parkinson's disease,Schizophrenia,Lung Cancer,Breast Cancer,Colo-Rectal Cancer,Blood Cancer,Prostate Cancer,siva.Fatal Familial Insomnia Factor V Leiden Mutation ,Epilepsy Dupuytren's disease,Desmoplastic small-round-cell tumor Diabetes ,Coeliac disease,Creutzfeldt–Jakob disease,Cerebral Amyloid Angiopathy, Ataxia,Arthritis,Amyotrophic Lateral Scoliosis,Fibromyalgia,Fluoroquinolone Toxicity
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  2. A world is enough for a wise. I'm SEN.BUKA MORRIS from DENMARK.I was a Herpes patient for 7years ,i suffered a great lost in applying medical treatment to get cure from the virus. It was too scaring having does sleepless nights with Herpes. I went through many hospitals seeking for the solution to my cure all my efforts where rendered useless. I was so frustrated, and lost my lovely wife along the line due to the bad effects of her virus. I became so ashamed of myself. I decided to check on the internet if there could be any possible remedy to this dangerous virus . Then,I came across lots of comments about Dr.CHUKWU MADU HERBAL HOME, who's patience have recommended him of his Good work,testifying how his medicine saved their lives, and there have been living happily negative of their virus. I thought and believe I could be cure as well. Then,I decided to give it a try. To my greatest surprise after contacting him.,I was very happy in our first chat and I believe in everything he said. He really proved to me after going through lots of pics and videos with his patients. I then ordered for his medicine , he prepared and sent it through the DHL service.It was like a joke,but now a dream come through that I'm Herpes free, I have recently been confirmed HSV negative. All thanks to God for showing me the way to Dr CHUKWU MADU HERBAL HOME the great and powerful herbalist. Reach this herbalist on his email [dr.chukwumaduherbalhome@gmail.com] or +2347030936239.

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  3. What a Miraculous Recovery!!!
    I will always remember you on this day Dr
    I was totally convinced before I could finished you medicine prepared for me for my Herpes. By Dr. Odey Abang,
    It was actually a sad incident and a painful soles still appearing and was still using the ancylovia ..
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    for you're cure to
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